<h1 align="center">The COnstraint-Based Reconstruction <br>and Analysis Toolbox</h1>
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    View The COBRA Toolbox <strong>source code</strong> on <a href="https://github.com/opencobra/cobratoolbox/"><img src="/cobratoolbox/stable/_static/img/github.png" height="40px" alt="github"></a>.
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            <div>Installation</div>
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<p>
The COnstraint-Based Reconstruction and Analysis Toolbox is a MATLAB software suite for quantitative prediction of cellular and multicellular biochemical networks with constraint-based modelling. It implements a comprehensive collection of basic and advanced modelling methods, including reconstruction and model generation as well as biased and unbiased model-driven analysis methods.</p>

<p>It is widely used for modelling, analysing and predicting a variety of metabolic phenotypes using genome-scale biochemical networks.</p>
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<h2>Cite the COBRA Toolbox v3.0</h2>
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Laurent Heirendt, Sylvain Arreckx, Thomas Pfau, Sebastian N.
Mendoza, Anne Richelle, Almut Heinken, Hulda S. Haraldsdottir, Jacek
Wachowiak, Sarah M. Keating, Vanja Vlasov, Stefania Magnusdottir,
Chiam Yu Ng, German Preciat, Alise Zagare, Siu H.J. Chan, Maike K.
Aurich, Catherine M. Clancy, Jennifer Modamio, John T. Sauls,
Alberto Noronha, Aarash Bordbar, Benjamin Cousins, Diana C. El
Assal, Luis V. Valcarcel, Inigo Apaolaza, Susan Ghaderi, Masoud
Ahookhosh, Marouen Ben Guebila, Andrejs Kostromins, Nicolas
Sompairac, Hoai M. Le, Ding Ma, Yuekai Sun, Lin Wang, James T.
Yurkovich, Miguel A.P. Oliveira, Phan T. Vuong, Lemmer P. El Assal,
Inna Kuperstein, Andrei Zinovyev, H. Scott Hinton, William A.
Bryant, Francisco J. Aragon Artacho, Francisco J. Planes, Egils
Stalidzans, Alejandro Maass, Santosh Vempala, Michael Hucka, Michael
A. Saunders, Costas D. Maranas, Nathan E. Lewis, Thomas Sauter,
Bernhard Ø. Palsson, Ines Thiele, Ronan M.T. Fleming, <b>Creation and
analysis of biochemical constraint-based models: the COBRA Toolbox
v3.0</b>, Nature Protocols, volume 14, pages 639–702, 2019
<a href="https://doi.org/10.1038/s41596-018-0098-2">doi.org/10.1038/s41596-018-0098-2</a>.
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<img class="avatar" src="https://opencobra.github.io/images/history.gif" alt="history"></img><br>
Evolution of the repository of <br><b>The COBRA Toolbox</b> (2016-2020).
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